2024

Recent Advancements in the Characterization of D-Amino Acid and Isoaspartate Post-Translational Modifications, S. Okyem, J.V. Sweedler, Mass Spectrom. Rev., 2024, online ahead of print. DOI:10.1002/mas.21916

Novel Repurposing of Sulfasalazine for the Treatment of Adrenocortical Carcinomas, Probably through the Slc7a11/Xct-Hsa-Mir-92a-3p-Oip5-As1 Network Pathway, C. Subramanian, K. McNamara, S.W. Croslow, Y. Tan, D. Hess, K. Kiseljak-Vassiliades, M.E. Wierman, J.V. Sweedler, M.S. Cohen, Surgery 2024, (online ahead of print). DOI:10.1016/j.surg.2024.07.075

1-Octanol-Assisted Ultra-Small Volume Droplet Microfluidics with Nanoelectrospray Ionization Mass Spectrometry, Y. Zhao, I. Park, S.S. Rubakhin, R. Bashir, Y. Vlasov, J.V. Sweedler, Anal. Chim. Acta 1321, 2024, 342998. DOI:10.1016/j.aca.2024.342998

Two C-Terminal Isoforms of Aplysia Tachykinin-Related Peptide Receptors Exhibit Phosphorylation-Dependent and Independent Desensitization Mechanisms, R.T. Mao, S.Q. Guo, G. Zhang, Y.D. Li, J.P. Xu, H.Y. Wang, P. Fu, C.P. Liu, S.Q. Wu, P. Chen, Y.S. Mei, Q.C. Jin, C.Y. Liu, Y.C. Zhang, X.Y. Ding, W.J. Liu, E.V. Romanova, H.B. Zhou, E.C. Cropper, J.W. Checco, J.V. Sweedler, J. Jing, J. Biol. Chem. 300, 2024, 107556. DOI:10.1016/j.jbc.2024.107556

A Novel Series of Metazoan L/D Peptide Isomerases, H.M. Andersen, H.C. Tai, S.S. Rubakhin, P.M. Yau, J.V. Sweedler, J. Biol. Chem. 300, 2024, 107458. DOI:10.1016/j.jbc.2024.107458

High-Resolution (1)H-MRSI at 9.4 T by Integrating Relaxation Enhancement and Subspace Imaging, Y. Wang, U. Saha, S.S. Rubakhin, E.J. Roy, A.M. Smith, J.V. Sweedler, F. Lam, NMR Biomed. 37, 2024, e5161. DOI:10.1002/nbm.5161

Neuronal Innervation Regulates the Secretion of Neurotrophic Myokines and Exosomes from Skeletal Muscle, K.Y. Huang, G. Upadhyay, Y. Ahn, M. Sakakura, G.J. Pagan-Diaz, Y. Cho, A.C. Weiss, C. Huang, J.W. Mitchell, J. Li, Y. Tan, Y.H. Deng, A. Ellis-Mohr, Z. Dou, X. Zhang, S. Kang, Q. Chen, J.V. Sweedler, S.G. Im, R. Bashir, H.J. Chung, G. Popescu, M.U. Gillette, M. Gazzola, H. Kong, Proc. Natl. Acad. Sci. U.S.A. 121, 2024, e2313590121. DOI:10.1073/pnas.2313590121

Nontargeted Identification of D-Amino Acid-Containing Peptides through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS, S. Okyem, E.V. Romanova, H.C. Tai, J.W. Checco, J.V. Sweedler, Methods Mol. Biol. 2758, 2024, 227–240. DOI:10.1007/978-1-0716-3646-6_12

Bioinformatics for Prohormone and Neuropeptide Discovery, B.R. Southey, E.V. Romanova, S.L. Rodriguez-Zas, J.V. Sweedler, Methods Mol. Biol. 2758, 2024, 151–178. DOI:10.1007/978-1-0716-3646-6_8

Single Cell Analysis of Proteoforms, P. Su, M.A.R. Hollas, F.A. Butun, V.L. Kanchustambham, S. Rubakhin, N. Ramani, J.B. Greer, B.P. Early, R.T. Fellers, M.A. Caldwell, J.V. Sweedler, J.O. Kafader, N.L. Kelleher, J. Proteome Res. 23, 2024, 1883–1893. DOI:10.1021/acs.jproteome.4c00075

Multiscale Biochemical Mapping of the Brain through Deep-Learning-Enhanced High-Throughput Mass Spectrometry, Y.R. Xie, D.C. Castro, S.S. Rubakhin, T.J. Trinklein, J.V. Sweedler, F. Lam, Nat. Methods 21, 2024, 521–530. DOI:10.1038/s41592-024-02171-3

Metabolic Insights from Mass Spectrometry Imaging of Biofilms: A Perspective from Model Microorganisms, D. Parmar, J.M. Rosado-Rosa, J.D. Shrout, J.V. Sweedler, Methods 224, 2024, 21–34. Featured in Special Issue: VSI Editors Collection – YMETH. DOI:10.1016/j.ymeth.2024.01.014

Advances in Multimodal Mass Spectrometry for Single-Cell Analysis and Imaging Enhancement, S.W. Croslow, T.J. Trinklein, J.V. Sweedler, FEBS Lett. 598, 2024, 591–601. DOI:10.1002/1873-3468.14798

Enhancing 2-Pyrone Synthase Efficiency by High-Throughput Mass-Spectrometric Quantification and in Vitro/in Vivo Catalytic Performance Correlation, Y. Zhou, S. Zhou, S. Lyons, H. Sun, J.V. Sweedler, Y. Lu, Chembiochem 25, 2024, e202300849. DOI:10.1002/cbic.202300849

A Blood Drying Process for DNA Amplification, J. Lim, S. Zhou, J. Baek, A.Y. Kim, E. Valera, J. Sweedler, R. Bashir, Small 20, 2024, 2307959. DOI:10.1002/smll.202307959

Probe-Based Mass Spectrometry Approaches for Single-Cell and Single-Organelle Measurements, D.C. Castro, P. Chan-Andersen, E.V. Romanova, J.V. Sweedler, Mass Spectrom. Rev. 43, 2024, 888–912. DOI:10.1002/mas.21841

NanoLC-timsTOF-Assisted Analysis of Glycated Albumin in Diabetes-Affected Plasma and Tears, Y. Tan, E.A. De La Toba, S.S. Rubakhin, D. Pan, L.T. Labriola, C. Canfield, J.V. Sweedler, J. Amer. Soc. Mass Spectrom. 35, 2024, 106–113. DOI:10.1021/jasms.3c00331

TOP

2023

Relations Between Glucose and D-Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans,C.J. Lee, D.-K. Lee, I.-A. Wei, S.S. Rubakhin, T.A. Qiu, M.G. Roper, J.V. Sweedler, ACS Omega 8, 2023, 47723–47734. DOI:10.1021/acsomega.3c05983

Differential Spreading of Rhamnolipid Congeners from Pseudomonas aeruginosa, A.A. Weaver, D. Parmar, E.A. Junker, J.V. Sweedler, J.D. Shrout, ACS Appl. Bio. Mater. 6, 2023, 4914–4921. DOI:10.1021/acsabm.3c00641

Development of a Cell-Free Strategy to Recover Aged Skeletal Muscle After Disuse, Y.-F. Wu, E. De La Toba, S. Dvoretskiy, R. Jung, N. Kim, L. Daniels, E.V. Romanova, J. Drnevich, J.V. Sweedler, M.D. Boppart, J. Physiol. 601, 2023, 5011–5031. [First published online, March 22, 2022, and held for Special Issue entitled: Extracellular Vesicles in Organ and Systems Function in Health and Disease.] DOI:10.1113/JP282867

Workflow for High-throughput Screening of Enzyme Mutant Libraries Using Matrix-assisted Laser Desorption/Ionization Mass Spectrometry Analysis of Escherichia coli Colonies, K. Choe and J.V. Sweedler, Bio-protocol 13, 2023, e4862. DOI:10.21769/BioProtoc.4862

Biodistribution and Racemization of Gut-Absorbed L/D-Alanine in Germ-Free Mice, T.A. Qiu, C.J. Lee, C. Huang, D.-K. Lee, S.S. Rubakhin, E. V. Romanova, J.V. Sweedler, Comm. Biol. 6, 2023, 851. DOI:10.1038/s42003-023-05209-y

Site-specific Chirality-conferred Structural Compaction Differentially Mediates the Cytotoxicity of Aβ42, G. Li, C. K. Jeon, M. Ma, Y. Jia, Z. Zheng, D.G. Delafield, G. Lu, E.V. Romanova, J.V. Sweedler, B.T. Ruotolo, L. Li, Chem. Sci. 14, 2023, 5936–5944. DOI:10.1039/D3SC00678F

MALDI-MS Screening of Microbial Colonies with Isomer Resolution to Select Fatty Acid Desaturase Variants, K. Choe, M.A. Jindra, S.C. Hubbard, B.F. Pfleger, J.V. Sweedler, Anal. Biochem. 672, 2023, 115169. DOI:10.1016/j.ab.2023.115169

Nonenzymatic Posttranslational Modifications and Peptide Cleavages Observed in Peptide Epimers, C.C. Long, A. Antevska, D.H. Mast, S. Okyem, J.V. Sweedler, T.D. Do, J. Am. Soc. Mass Spectrom. 34, 2023, 1898–1907. DOI:10.1021/jasms.3c00092

Single-Cell and Subcellular Analysis Using Ultrahigh Resolution 21 T MALDI FTICR Mass Spectrometry, D.C. Castro, K.W. Smith, M.D. Norsworthy, S.S. Rubakhin, C.R. Weisbrod, C.L. Hendrickson, J.V. Sweedler, Anal. Chem. 95, 2023, 6980–6988. DOI:10.1021/acs.analchem.3c00393

Chemical Decrosslinking-Based Peptide Characterization of Formaldehyde-Fixed Rat Pancreas Using Fluorescence-Guided Single-Cell Mass Spectrometry, D.K. Lee, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 95, 2023, 6732–6739. DOI:10.1021/acs.analchem.3c00612

Peptidomics, R. Hellinger, A. Sigurdsson, W. Wu, E.V. Romanova, L. Li, J.V. Sweedler, R.D. Süssmuth, C.W. Gruber, Nat. Rev. Methods Primers 3, 2023, 25. DOI:10.1038/s43586-023-00205-2

Evaluation of Strategies to Narrow the Product Chain-Length Distribution of Microbially Synthesized Free Fatty Acids, M.A. Jindra, K. Choe, R. Chowdhury, R. Kong, S. Ghaffari, J.V. Sweedler, B.F. Pfleger, Metab. Eng. 77, 2023, 21–31. DOI:10.1016/j.ymben.2023.02.012

Subcellular Omics: A New Frontier Pushing the Limits of Resolution, Complexity and Throughput, J. Eberwine, J. Kim, R.C. Anafi, S. Brem, M. Bucan, S.A. Fisher, M.S. Grady, A.E. Herr, D. Issadore, H. Jeong, H. Kim, D. Lee, S. Rubakhin, J.Y. Sul, J.V. Sweedler, J.A. Wolf, K.S. Zaret, J. Zou, Nat. Methods 20, 2023, 331–335. DOI:10.1038/s41592-023-01788-0

Assessment and Comparison of Database Search Engines for Peptidomic Applications, E.A. De La Toba, K.D.B. Anapindi, J.V. Sweedler, J. Proteome Res. 22, 2023, 3123–3134. DOI:10.1021/acs.jproteome.2c00307

Mass Spectrometry-Based High-Throughput Quantification of Bioproducts in Liquid Culture, S. Zhou, Z. Fatma, P. Xue, S. Mishra, M. Cao, H. Zhao, J.V. Sweedler, Anal. Chem. 95, 2023, 4067–4076. DOI:10.1021/acs.analchem.2c04845

Data-Driven and Machine Learning-Based Framework for Image-Guided Single-Cell Mass Spectrometry, X.R. Xie, V.K. Chari, D.C. Castro, R. Grant, S.S. Rubakhin, J.V. Sweedler, J. Proteome Res. 22, 2023, 491–500. DOI:10.1021/acs.jproteome.2c00714

Integrated Silicon Microfluidic Chip for Picoliter-Scale Analyte Segmentation and Microscale Printing for Mass Spectrometry Imaging, W. Shi, S. Bell, H. Iyer, C.K. Brenden, Y. Zhang, S. Kim, I. Park, R. Bashir, J. Sweedler, Y. Vlasov, Lab Chip 23, 2023, 72-80. DOI:10.1039/d2lc00688j

Effect of Micro-Patterned Mucin on Quinolone and Rhamnolipid Profiles of Mucoid Pseudomonas aeruginosa under Antibiotic Stress, J. Jia, D. Parmar, J.F. Ellis, T. Cao, A.R.Cutri, J.D.Shrout, J.V. Sweedler, P.W. Bohn, ACS Infect. Dis. 9, 2023, 150–161. DOI:10.1021/acsinfecdis.2c00519

TOP

2022

Single Cell Metabolism: Current and Future Trends, A. Ali, S. Davidson, E. Fraenkel, I. Gilmore, T. Hankemeier, J.A. Kirwan, A.N. Lane, I. Lanekoff, M. Larion, L.I. McCall, M. Murphy, J.V. Sweedler, C. Zhu, Metabolomics 18, 2022, 77. DOI:10.1007/s11306-022-01934-3

Attomole-Level Multiplexed Detection of Neurochemicals in Picoliter Droplets by on-Chip Nanoelectrospray Ionization Coupled to Mass Spectrometry, Y. Zhang, K. Li, Y. Zhao, W. Shi, H. Iyer, S. Kim, C. Brenden, J.V. Sweedler, Y. Vlasov, Anal. Chem. 94, 2022, 13804–13809. DOI:10.1021/acs.analchem.2c02323

D-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans, C.J. Lee, J.H. Schnieders, S.S. Rubakhin, A.V. Patel, C. Liu, A. Naji, J.V. Sweedler, Metabolites 12, 2022, 799. DOI:10.3390/metabo12090799

Profiling 26,000 Aplysia Californica Neurons by Single Cell Mass Spectrometry Reveals Neuronal Populations with Distinct Neuropeptide Profiles, P.C. Chan-Andersen, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, J. Biol. Chem. 298, 2022, 102254. DOI:10.1016/j.jbc.2022.102254

Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure, H.E. Rymut, L.A. Rund, B.R. Southey, R.W. Johnson, J.V. Sweedler, S.L. Rodriguez-Zas, Genes (Basel) 13, 2022, 1371. DOI:10.3390/genes13081371

Profiling of D-Alanine Production by the Microbial Isolates of Rat Gut Microbiota, C.J. Lee, T.A. Qiu,. Z. Hong, Z. Zhang, Y. Min, L. Zhang, L. Dai, H. Zhao, T. Si, J.V. Sweedler, FASEB J. 36, 2022, e22446. DOI:10.1096/fj.202101595R

Rapid Determination of RNA Modifications in Consensus Motifs by Nuclease Protection with Ion-Tagged Oligonucleotide Probes and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry, M.E. Melzer, J.V. Sweedler, K.D. Clark, Genes (Basel) 13, 2022, 1008. DOI:10.3390/genes13061008

Metabolomics-Based Mass Spectrometry Methods to Analyze the Chemical Content of 3D Organoid Models, S.E. Murphy and J.V. Sweedler, Analyst 147, 2022, 2918–2929. DOI:10.1039/d2an00599a

Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics, K.D. B. Anapindi, E.V. Romanova, J.W. Checco, J.V. Sweedler, Pharmacol. Rev. 74, 2022, 662–679. DOI:10.1124/pharmrev.121.000423

Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation, E.A. De La Toba, S.E. Bell, E.V. Romanova, J.V. Sweedler, Annu. Rev. Anal. Chem. (Palo Alto Calif.) 15, 2022, 83–106. DOI:10.1146/annurev-anchem-061020-022048

Characterizing RNA Modifications in Single Neurons using Mass Spectrometry, K.D. Clark, S.S. Rubakhin, J.V. Sweedler, J. Vis. Exp. (182), 2022, e63940. DOI:10.3791/63940

Enhancing the Throughput of FT Mass Spectrometry Imaging Using Compressed Sensing and Subspace Modeling, Y.R. Xie, D.C. Castro, S.S. Rubakhin, J.V. Sweedler, F. Lam, Anal. Chem. 94, 2022, 5335–5343. DOI:10.1021/acs.analchem.1c05279

Droplet-Assisted Electrospray Phase Separation Using An Integrated Silicon Microfludic Platform, Y. Zhang, S. Kim, W. Shi, Y. Zhao, I. Park, C. Brenden, H. Iyer, P. Jha, R. Bashir, J.V. Sweedler, Y. Vlasov, Lab Chip 22, 2022, 40–46. DOI:10.1039/D1LC00758K

TOP

2021

Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs, C.A. Lee, E.V. Romanova, B.R. Southey, R. Gillette, J.V. Sweedler, Front. Aquat. Physiol. 12, 2021, 809529. DOI:10.3389/fphys.2021.809529

Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain, A. Bhaduri, E.K. Neumann, A.R. Kriegstein, J.V. Sweedler, JACS Au 1, 2021, 2261−2270. DOI:10.1021/jacsau.1c00393

Physiopathological Relevance of D-Serine in the Mammalian Cochlea, J. Wang, N. Serratrice, C.J. Lee, J.V. Sweedler, J-L. Puel, J.P. Mothet, J. Ruel, Front. Cell. Neurosci. 15, 2021, 733004. DOI:10.3389/fncel.2021.733004

Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia, P. Zhang, O.C. Perez, B.R. Southey, J.V. Sweedler, A.A. Pradhan, S.L. Rodriguez-Zas, Genes (Basel) 12, 2021, 1570. DOI:10.3390/genes12101570

Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution, K.D. Clark, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 93, 2021, 14537–14544. DOI:10.1021/acs.analchem.1c03507

Image-Guided MALDI Mass Spectrometry for High-throughput Single-Organelle Characterization, D.C. Castro, Y.R. Xie, S.S. Rubakhin, E.V. Romanova, J.V. Sweedler, Nat. Methods 18, 2021, 1233–1238. DOI:10.1038/s41592-021-01277-2

Droplet Microfluidics with MALDI-MS Detection: The Effects of Oil Phases in GABA Analysis, S.E. Bell, I. Park, S.S. Rubakhin, R. Bashir, Y. Vlasov, J.V. Sweedler, ACS Meas. Sci. Au 1, 2021, 147−156. DOI:10.1021/acsmeasuresciau.1c00017

Characterization of Neuronal RNA Modifications during Non-associative Learning in Aplysia Reveals Key Roles for tRNAs in Behavioral Sensitization, K.D. Clark, C. Lee, R. Gillette, J.V. Sweedler, ACS Central Sci. 7, 2021, 1183–1190. DOI: 10.1021/acscentsci.1c00351

Analysis of Peptide Stereochemistry in Single Cells by Capillary Electrophoresis-Trapped Ion Mobility Spectrometry Mass Spectrometry, D.H. Mast, H-W. Liao, E.V. Romanova, J.V. Sweedler, Anal. Chem. 93, 2021, 6205–6213. DOI:10.1021/acs.analchem.1c00445

Spatiotemporal Biodistribution of α-tocopherol is Impacted by the Source of 13C-labeled α-tocopherol in Mice following a Single Oral Dose, S. Jeon, Q. Li., K.M. Ranard, S.S. Rubakhin, J.V. Sweedler, M.J. Kuchand, J.W. Erdman, Nutr. Res. 93, 2021, 79–86. DOI:10.1016/j.nutres.2021.07.005

macroMS: An Image-Guided Analysis of Random Objects by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, K. Choe, P. Xue, H. Zhao, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 32, 1180–1188. DOI:10.1021/jasms.1c00013

Effects of Maternal Immune Activation in Porcine Transcript Isoforms of Neuropeptide and Receptor Genes, B.R. Southey, P. Zhang, M.R. Keever, H.E. Rymut, R.W. Johnson, J.V. Sweedler, S.L. Rodriguez-Zas, J. Integr. Neurosci. 20, 2021, 21–31. Online Open Access.

Biopolymer Patterning-Directed Secretion in Mucoid and Non-Mucoid Strains of Pseudomonas aeruginosa Revealed by Multimodal Chemical Imaging, J. Jia, J.F. Ellis, T. Cao, K. Fu, N. Morales-Soto, J.D. Shrout, J.V. Sweedler, P.W. Bohn, ACS Infect. Dis. 7, 2021, 598–607. DOI:10.1021/acsinfecdis.0c00765

Enhanced Understanding of Molecular Interactions and Function Underlying Pain Processes Through Networks of Transcript Isoforms, Genes, and Gene Families, P. Zhang, B.R. Southey, J.V. Sweedler, A. Pradhan, S.L. Rodriguez-Zas, Adv. Appl. Bioinform. Chem. 14, 2021, 49–69. DOI:10.2147/AABC.S284986

3D Particle-Free Printing of Biocompatible Conductive Hydrogel Platforms for Neuron Growth and Electrophysiological Recording, C. Wang, S.S. Rubakhin, M.J. Enright, J.V. Sweedler, R.G. Nuzzo, Adv. Funct. Mater. 31, 2021, 2010246. DOI:10.1002/adfm.202010246

Advancing D-Amino Acid-Containing Peptide Discovery in the Metazoan, D.H. Mast, J.W. Checco, J.V. Sweedler, Biochim. Biophys. Acta Proteins Proteom. 1869, 2021, 140553. DOI:10.1016/j.bbapap.2020.140553 

TOP

2020

Accelerating Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry Imaging Using a Subspace Approach, Y.R. Xie, D.C. Castro, F. Lam, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 31, 2020, 2338–2347. DOI:10.1021/jasms.0c00276

Biphasic Liquid Microjunction Extraction for Profiling Neuronal RNA Modifications by Liquid Chromatography-Tandem Mass Spectrometry, K.D. Clark, M.C. Philip, Y. Tan, J.V. Sweedler, Anal. Chem. 92, 2020, 12647–12655.  DOI:10.1021/acs.analchem.0c02830

Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues, D-K Lee, S.S. Rubakhin, I. Kusmartseva, C. Wasserfall, M.A. Atkinson, J.V. Sweedler, Angew. Chem. Int. Ed. Engl. 59, 2020, 22584–22590. DOI:10.1002/anie.202008847

Spatiotemporal Distribution of Pseudomonas aeruginosa Alkyl Quinolones Under Metabolic and Competitive Stress, T. Cao, J.V. Sweedler, P.W. Bohn, J.D. Shrout, mSphere 5, 2020, e00426-20. DOI:10.1128/mSphere.00426-20

D-Alanine: Distribution, Origin, Physiological Relevance, and Implications in Disease, C.J. Lee, T. Qiu, J.V. Sweedler, Biochim. Biophys. Acta Proteins Proteom. 1868, 2020, 140482. DOI:10.1016/j.bbapap.2020.140482

Single-Cell Classification Using Mass Spectrometry Through Interpretable Machine Learning, Y.R. Xie, D.C. Castro, S.E. Bell, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 92, 2020, 9338–9347. DOI:10.1021/acs.analchem.0c01660

Enhanced Single-Cell Metabolomics by Capillary Electrophoresis Electrospray Ionization-Mass Spectrometry with Field Amplified Sample Injection, H-W. Liao, S.S. Rubakhin, M.C. Philip, J.V. Sweedler, Anal. Chim. Acta 1118, 2020, 36–43.
DOI:10.1016/j.aca.2020.04.028

Quantitative Imprint Mass Spectrometry Imaging of Endogenous Ceramides in Rat Brain Tissue with Kinetic Calibration, Q. Wu, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 92, 2020, 6613–6621. DOI:10.1021/acs.analchem.0c00392

A Mass Spectrometry-based High-throughput Screening Method for Engineering Fatty Acid Synthases with Improved Production of Medium Chain Fatty Acids, P. Xue, T. Si, S. Mishra, L. Zhang, K. Choe, J.V. Sweedler, H. Zhao, Biotechnol. Bioeng. 117, 2020, 2131–2138. DOI:10.1002/bit.27343

Quantitative Characterization of the Neuropeptide Level Changes in Dorsal Horn and Dorsal Root Ganglia Regions of the Murine Itch Models, E.G. Tillmaand, K.D.B. Anapindi, E. De La Toba, C.J. Guo, J. Krebs, A.N. Lenhart, J.V. Sweedler, Q. Liu, J. Proteome Res. 19, 2020, 1248–1257. DOI:10.1021/acs.jproteome.9b00758

Differential Post-translational Amino Acid Isomerization Found Among Neuropeptides in Aplysia californica, D.H. Mast, J.W. Checco, J.V. Sweedler, ACS Chem. Biol. 15, 2020, 272–281. DOI:10.1021/acschembio.9b00910

TOP

2019

PACAP and Other Neuropeptides Link Chronic Migraine and Opioid-Induced Hyperalgesia in Mouse Models, K.D.B. Anapindi, N. Yang, E.V. Romanova, S.S. Rubakhin, A. Tipton, I. Dripps, Z. Sheets, J.V. Sweedler, A.A. Pradhan, Mol. Cell. Proteomics 18, 2019, 2447–2458. DOI:10.1074/mcp.RA119.001767

A Rotifer-Derived Paralytic Compound Prevents Transmission of Schistosomiasis to a Mammalian Host, J. Gao, N. Yang, F.A. Lewis, P. Yau, J.J. Collins, 3rd, J.V. Sweedler, P.A. Newmark, PLOS Biol. 17, 2019, e3000485. DOI:10.1371/journal.pbio.3000485

Multidimensional Top-Down Proteomics of Brain Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol, H.-M. Park, R. Satta, R.G. Davis, Y.A. Goo, R.D. LeDuc, R.T. Fellers, J.B. Greer, E.V. Romanova, S.S. Rubakhin, R. Tai, P.M. Thomas, J.V. Sweedler, N.L. Kelleher, S.M. Patrie, A.W. Lasek, J. Proteome Res. 18, 2019, 3999–4012. DOI:10.1021/acs.jproteome.9b00481

Seasonal Adaptations of the Hypothalamo-Neurohypophyseal System of the Dromedary Camel, F.Z.D. Alim, E.V. Romanova, Y.L. Tay, A. Rahman, K.G. Chan, K.W. Hong, M. Rogers, B.R. Southey, M.P. Greenwood, A.S. Mecawi, M.R. Mustafa, N. Mahy, C. Campbell, J. Antunes-Rodrigues, J.V. Sweedler, D. Murphy, C.C.T. Hindmarch, PLOS ONE 14, 2019, e0216679. DOI:10.1371/journal.pone.0216679

Opioid-Induced Hyperalgesia is Associated with Dysregulation of Circadian Rhythm and Adaptive Immune Pathways in the Mouse Trigeminal Ganglia and Nucleus Accumbens, P. Zhang, L.S. Moye, B.R. Southey, I. Dripps, J.V. Sweedler, A. Pradhan, S.L. Rodriguez-Zas, Mol. Neurobiol. 56, 2019, 7929–7949. DOI:10.1007/s12035-019-01650-5

Lipid Analysis of 30 000 Individual Rodent Cerebellar Cells using High-Resolution Mass Spectrometry, E.K. Neumann, J.F. Ellis, A.E. Triplett, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 91, 2019, 7871–7878. DOI:10.1021/acs.analchem.9b01689

Lipid Heterogeneity between Astrocytes and Neurons Revealed by Single-Cell MALDI-MS Combined with Immunocytochemical Classification, E.K. Neumann, T.J. Comi, S.S. Rubakhin, J.V. Sweedler, Angew. Chemie Int. Ed. 58, 2019, 5910–5914. DOI:10.1002/anie.201812892

Investigating Brain D-Serine: Advocacy for Good Practices, J.P. Mothet, J.M. Billard, L. Pollegioni, J.T. Coyle, J.V. Sweedler, Acta Physiol (Oxf.) 226, 2019, e13257. DOI:10.1111/apha.13257

Exploring the Fundamental Structures of Life: Non-targeted, Chemical Analysis of Single Cells and Subcellular Structures, E.K. Neumann, T.D. Do, T.J. Comi, J.V. Sweedler, Angew. Chemie Int. Ed. Engl. 58, 2019, 9348–9364. DOI:10.1002/anie.201811951

¹³C-Lutein is Differentially Distributed in Tissues of an Adult Female Rhesus Macaque Following a Single Oral Administration: A Pilot Study, S. Jeon, Q. Li, S.S. Rubakhin, J.V. Sweedler, J.W. Smith, M. Neuringer, M. Kuchan, J.W. Erdman, Nutr. Res. 61, 2019, 102–108. DOI:10.1016/j.nutres.2018.10.007

TOP

2018

Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia, H. Jeong, L.S. Moye, B.R. Southey, A.G. Hernandez, I. Dripps, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, A.A. Pradhan, S.L. Rodriguez-Zas, Front. Sys. Neurosci. 12, 2018, 63. DOI:10.3389/fnsys.2018.00063

Exploring Exercise- and Context-Induced Peptide Changes in Mice by Quantitative Mass Spectrometry, S.E. Dowd, M.L. Mustroph, E.V. Romanova, B.R. Southey, H. Pinardo, J.S. Rhodes, J.V. Sweedler,  ACS Omega 3, 2018, 13817–13827. DOI:10.1021/acsomega.8b01713

Rapid Screening of Lanthipeptide Analogs Via in-Colony Removal of Leader Peptides in Escherichia Coli, T. Si, Q. Tian, Y. Min, L. Zhang, J.V. Sweedler, W.A. van der Donk, H. Zhao, J. Am. Chem. Soc. 140, 2018, 11884–11888. DOI:10.1021/jacs.8b05544

Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging, E.K. Neumann, T.J. Comi, N. Spegazzini, J.W. Mitchell, S.S. Rubakhin, M.U. Gillette, R. Bhargava, J.V. Sweedler, Anal. Chem. 90, 11572–11580, 2018. DOI:10.1021/acs.analchem.8b02913

Aplysia Allatotropin-related Peptide and its Newly identified D-Amino Acid-containing Epimer both Activate a Receptor and a Neuronal Target, J.W. Checco, G. Zhang, W.-D. Yuan, Z.-W. Le, J. Jing, J.V. Sweedler, J. Biol. Chem. 293, 16862–16873. DOI:10.1074/jbc.RA118.004367

Conformational Investigation of the Structure – Activity Relationship of GdFFD and Its Analogues on an Achatin-like Neuropeptide Receptor of Aplysia californica Involved in the Feeding Circuit, T.D. Do, J.W. Checco, M.Tro, J.-E. Shea, M.T. Bowers, J.V. Sweedler, Phys. Chem. Chem. Phys. 20, 2018, 22047–22057. DOI:10.1039/C8CP03661F

Interrogation of Spatial Metabolome of Ginkgo biloba with High-resolution MALDI and LDI Mass Spectrometry Imaging, B. Li, E.K. Neumann, W.Gao, H. Yang, P. Li, J.V. Sweedler, Plant Cell Environ. 41, 2018, 2693–2703. DOI:10.1111/pce.13395

Animal Model Systems in Neuroscience, Editorial by E.V. Romanova and J.V. Sweedler (guest editors), ACS Chem. Neurosci. 9, 2018, 1869–1870. DOI: 10.1021/acschemneuro.8b00380.  View this Special Issue on Model Systems in Neuroscience here.

cAMP, Ca²⁺, pHi, and NO Regulate H-Like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea-Slug Pleurobranchaea californica, D.J. Green, R.C. Huang, L. Sudlow, N.G. Hatcher, K. Potgieter, C.R. McCrohan, C. Lee, E.V. Romanova, J.V. Sweedler, M.U. Gillette, R.G. Gillette, ACS Chem. Neurosci. 9, 1986–1993. DOI:10.1021/acschemneuro.8b00187

Functional Peptidomics: Stimulus- and Time-of-Day-Specific Peptide Release in the Mammalian Circadian Clock, N. Atkins, Jr., S. Ren, N. Hatcher, P.W. Burgoon, J.W. Mitchell, J.V. Sweedler, M.U. Gillette, ACS Chem. Neurosci. 9, 2018, 2001–2008. DOI:10.1021/acschemneuro.8b00089

Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function, G. Zhang, W-D. Yuan,  F.S. Vilim, E.V. Romanova, K.Yu, S-Y. Yin, Z-W. Le, Y-Y. Xue, T-T. Chen, G-K. Chen, S-A. Chen, E.C. Cropper, J.V. Sweedler, K.R. Weiss, J. Jing, ACS Chem. Neurosci. 9, 2041–2053. DOI:10.1021/acschemneuro.7b00513

Disruption of Microglia Histone Acetylation and Protein Pathways in Mice Exhibiting Inflammation-Associated Depression-Like Symptoms, S.L. Rodriguez-Zas, C. Wu, B.R. Southey, J.C. O’Connor, S.E. Nixon, R. Garcia, C. Zavala, M. Lawson, R.H. McCusker, E.V. Romanova, J.V. Sweedler, K.W. Kelley, R. Dantzer, Psychoneuroendocrinology 97, 2018, 47–58. DOI:10.1016/j.psyneuen.2018.06.024

Quantitative SIMS Imaging of Agar-Based Microbial Communities, S.J.B. Dunham, J.F. Ellis, N.F. Baig, N. Morales-Soto, T. Cao, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem. 90, 2018, 5654–5663. DOI:10.1021/acs.analchem.7b05180

Integrating Mass Spectrometry with Microphysiological Systems for Improved Chemical Information, E.G. Tillmaand and J.V. Sweedler, Microphysiol. Syst. 2, 2018, 4. DOI:10.21037/mps.2018.05.01

A Versatile Strategy for Characterization and Imaging of Drip Flow Microbial Biofilms, B. Li, S.J.B. Dunhan, J.F. Ellis, J.D. Lange, J.R. Smith, N. Yang, T.L. King, K.R. Amaya, C.M. Arnett, J.V. Sweedler, Anal. Chem. 90, 2018, 6725–6734. DOI:10.1021/acs.analchem.8b00560

Single Synaptic Observation of Cholinergic Neurotransmission on Living Neurons: Concentration and Dynamics, M. Shen, Z. Qu, J. DesLaurier, T.M. Welle, J.V. Sweedler, R.Chen, J. Am. Chem. Soc. 140, 2018, 7764–7768. DOI:10.1021/jacs.8b01989

A High Spatiotemporal Study of Somatic Exocytosis with Scanning Electrochemical Microscopy and NanoITIES Electrodes, T.M. Welle, K. Alanis, M.L. Colombo, J.V. Sweedler, M. Shen, Chem. Sci. 9, 2018, 4937–4941. DOI:10.1039/C8SC01131A

Spatially-dependent Alkyl Quinolone Signaling Responses to Antibiotics in Pseudomonas aeruginosa Swarms, N. Morales-Soto, S.J.B. Dunham, N.F. Baig, J.F..Ellis, C.S. Madukoma, P.W. Bohn, J.V. Sweedler, J.D. Shrout, J. Biol. Chem. 293, 2018, 9544–9552. DOI:10.1074/jbc.RA118.002605

Exploring the Sea Urchin Neuropeptide Landscape by Mass Spectrometry, E.B. Monroe, S.P. Annangudi, A.A. Wadhams, T.A. Richmond, N. Yang, B.R. Southey, E.V. Romanova, L. Schoofs, G. Baggerman, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 29, 2018, 923–934. DOI:10.1007/s13361-018-1898-x

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms between Mouse Strains, R.G. Davis, H.-M. Park, K. Kim, J.B. Greer, R.T. Fellers, R.D. LeDuc, E.V. Romanova, S.S. Rubakhin, J.A. Zombeck, C. Wu, P.M. Yau, P. Gao, A.J. van Nispen, S.M. Patrie, P.M. Thomas, J.V. Sweedler, J.S. Rhodes, N.L. Kelleher, Anal. Chem. 90, 2018, 3802–3810. DOI:10.1021/acs.analchem.7b04108

Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins, T.D. Do, J.F. Ellis, E.K. Neumann, T. J. Comi, E.G. Tillmaand, A.M. Lenhart, S.S. Rubakhin, J.V. Sweedler, ChemPhysChem., 2018, 1180–1191. DOI:10.1002/cphc.201701364

Molecular and Physiological Characterization of a D-Amino Acid-Containing Neuropeptide Receptor, J.W. Checco, G. Zhang, W. Yuan, K. Yu, S. Yin, R.H. Roberts-Galbraith, P.M. Yau, E.V. Romanova, J. Jing, J.V. Sweedler, ACS Chem. Biol. 13, 2018, 1343–1352. DOI:10.1021/acschembio.8b00167

Neuropeptidomics of the Rat Habenular Nuclei, N. Yang, K.D.B. Anapindi, S.S. Rubakhin, P. Wei, Q. Yu, L. Li, P.J. Kenny, J.V. Sweedler, J. Proteome Res. 17, 2018, 1463–1473. DOI:10.1021/acs.jproteome.7b00811

Non-Targeted Identification of D-Amino Acid-Containing Peptides through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS, H.C. Tai, J.W. Checco, J.V. Sweedler, Methods Mol. Biol. 1719, 2018, 107–118. DOI:10.1007/978-1-4939-7537-2_7

Bioinformatics for Prohormone and Neuropeptide Discovery, B.R. Southey, E.V. Romanova, S.L. Rodriguez-Zas, J.V. Sweedler, Methods Mol. Biol. 1719, 2018, 71–96. DOI:10.1007/978-1-4939-7537-2_5

Peptide Identifications and False Discovery Rates using Different Mass Spectrometry Platforms, K.D.B. Anapindi, E. V. Romanova, B.R. Southey, J.V. Sweedler, Talanta 182, 2018,456–463. DOI:10.1016/j.talanta.2018.01.062

The Effects of Ageing on Biosynthetic Processes in the Rat Hypothalamic Osmoregulatory Neuroendocrine System, M. Greenwood, E.V. Romanova; A.S. Mecawi, A.R. Paterson, O. Sarenac, N. Japundžić-Žigon, J. Antunes-Rodrigues, J.F. Paton, J.V. Sweedler, D. Murphy, Neurobiol. Aging 65, 2018, 178–191. DOI:10.1016/j.neurobiolaging.2018.01.008

Single Cell Neurometabolomics, M. Qi, M.C. Philip, N. Yang, J.V. Sweedler, ACS Chem. Neurosci. 9, 2018, 40–50. DOI:10.1021/acschemneuro.7b00304

Expired Epinephrine Maintains Chemical Concentration and Sterility, W.B. Weir, L.Y. Fred, M. Pike, S.S. Rubakhin, T.J. Ludwig, A.M. Shar, L. Zhu, A. Frederick, I. Uzoaru, L. Wang, J.V. Sweedler, Prehosp. Emerg. Care, 2018, 1–5. DOI:10.1080/10903127.2017.1402109

TOP

2017

Chiral Measurement of Aspartate and Glutamate in Single Neurons by Large-Volume Sample Stacking Capillary Electrophoresis, A.V. Patel, T. Kawai, L. Wang, S.S. Rubakhin,  J.V. Sweedler, Anal. Chem. 89, 2017, 12375–12382. DOI:10.1021/acs.analchem.7b03435

Improved Identification and Quantitation of Mature Endogenous Peptides in Rodent Hypothalamus with the Use of a Rapid Conductive Heating System, N. Yang, K. Anapindi, S.S. Rubakhin, E.V. Romanova, .J.V. Sweedler, Analyst 142, 2017, 4476–4485. DOI:10.1039/C7AN01358B

Three-Dimensional Mesostructures as High-Temperature Growth Templates, Electronic Cellular Scaffolds, and Self-Propelled Microrobots, Z. Yan, M. Han, Y. Shi, A. Badea, Y. Yang, A. Kulkarni, E. Hanson, M.E. Kandel, X. Wen, F. Zhang, Y. Luo, Q. Lin, H. Zhang, X. Guo, Y. Huang, K. Nan, S. Jia, A.W. Oraham, M.B. Mevis, J. Lim, X. Guo, M. Gao, W. Ryu, K.J. Yu, B.G. Nicolau, A. Petronico, S.S. Rubakhin, J. Lou, P.M. Ajayan, K. Thornton, G. Popescu, D. Fang, J.V. Sweedler, P.V. Braun, H. Zhang, R.G. Nuzzo, Y. Huang, Y. Zhang, J.A. Rogers, Proc. Natl. Acad. Sci., U.S.A. 114, 2017, E9455–E9464. DOI:10.1073/pnas.1713805114

Discovery of Leucokinin-like Neuropeptides that Modulate a Specific Parameter of Feeding Motor Programs in the Molluscan Model, Aplysia, G. Zhang, F.S. Vilim, D.-D. Liu, E.V. Romanova, K. Yu, W.-D. Yuan, H. Xiao, A.B. Hummon, T.-T. Chen, V. Alexeeva, S.-Y. Yin, S.-A. Chen, E.C Cropper, J.V. Sweedler, K.R Weiss, J. Jing, J. Biol. Chem. 292, 2017, 18775–18789. DOI:10.1074/jbc.M117.795450

MALDI MS Guided Liquid Microjunction Extraction for Capillary Electrophoresis–Electrospray Ionization MS Analysis of Single Pancreatic Islet Cells, T.J. Comi, M.A. Makurath, M.C. Philip, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 89, 2017, 7765–7772. DOI:10.1021/acs.analchem.7b01782

Profiling of Microbial Colonies for High-throughput Engineering of Multi-step Enzymatic Reactions via Optically Guided MALDI MS, T. Si, B. Li, T. J. Comi, Y. Wu, P. Hu, Y. Wu, Y. Min, D. A. Mitchell, H. Zhao, J.V. Sweedler, J. Am. Chem. Soc. 139, 2017, 12466–12473. DOI:10.1021/jacs.7b04641

3D-Printed pHEMA Materials for Topographical and Biochemical Modulation of Dorsal Root Ganglion Cell Response, A. Badea, J.M. McCracken, E. Tillmaand, M. Kandel, A. Oraham, M. Mevis, S.S. Rubakhin, G. Popescu, J.V. Sweedler, R. Nuzzo, ACS Appl. Mat. Interfaces 9, 2017, 30318–30328. DOI:10.1021/acsami.7b06742

Microscale Transport Physics  During Atomic Force Microscopy Mass Spectrometry and Improved Sampling Efficiency,  H. Moon, T. J. Comi, S. J. B. Dunham, B. Kwon, J. V. Sweedler, W. P. King, In 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2017, 24–27. DOI:10.1109/TRANSDUCERS.2017.7993978

Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks, J. M. McCracken, S. Xu, A. Badea, K.-I. Jang, Z. Yan, D. J. Wetzel, K. Nan, Q. Lin, M. Han, M. A. Anderson, J. W. Lee, Z. Wei, M. Pharr, R. Wang, J. Su, S. S. Rubakhin, J. V. Sweedler, J. A. Rogers, R. G. Nuzzo, Adv. Biosys. 1, 2017, 1700068. DOI:10.1002/adbi.201700068

microMS: A Python Platform for Image-guided Mass Spectrometry Profiling, T.J. Comi, E.K. Neumann, T.D. Do, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 28, 2017, 1919–1928. DOI:10.1007/s13361-017-1704-1

Quantitative Reflection Imaging for Morphology and Dynamics of Live Aplysia Californica Pedal Ganglion Neurons Cultured on Nanostructured Plasmonic Crystals, S. Kang, A. Badea, S.S. Rubakhin, J.V. Sweedler, J. Rogers, R. Nuzzo, Langmuir 33, 2017, 8640–8650. DOI:10.1021/acs.langmuir.6b04454

Dopamine-Modified TiO2 Monolith-Assisted LDI MS Imaging: Development and Application to Simultaneous Localization of Small Metabolites and Large Lipids in Mouse Brain Tissue with High Detection Selectivity and Sensitivity, Q. Wu, J.L. Chu, S.S. Rubakhin, M.U. Gillette, J.V. Sweedler, Chem. Sci. 8, 2017, 3926–3938. DOI:10.1039/C7SC00937B

Single Cell Profiling using Ionic Liquid Matrix-Enhanced Secondary Ion Mass Spectrometry for Neuronal Cell Type Differentiation, T.D. Do, T.J. Comi, S.J.B. Dunham, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 89, 2017, 3078–3086. DOI:10.1021/acs.analchem.6b04819

Categorizing Cells Based on their Chemical Profiles: Progress in Single Cell Mass Spectrometry, T.J. Comi, T.D. Do, S.S. Rubakhin, J.V. Sweedler, J. Am. Chem. Soc. 139, 2017, 3920–3929. DOI:10.1021/jacs.6b12822

A Unique Combination of Micronutrients Rejuvenates Cognitive Performance in Aged Mice, S.D. Perez, K. Du, C. Rendeiro, L. Wang, Q. Wu, S.S. Rubakhin, R. Vazhappilly, J.H. Baxter, J.V. Sweedler, J.S. Rhodes, Behav. Brain Res. 320, 2017, 97–112. DOI:10.1016/j.bbr.2016.11.019

Mass Spectrometry Imaging of Complex Microbial Communities, S.J.B. Dunham, J.F. Ellis, B.Li, J.V. Sweedler, Acc. Chem. Res. 50, 2017, 96–104. DOI:10.1021/acs.accounts.6b00503

Carrot Solution Culture Bioproduction of Uniformly Labeled 13c-Lutein and in Vivo Dosing in Non-Human Primates, J.W. Smith, R.B. Rogers, S. Jeon, S.S. Rubakhin, L. Wang, J.V. Sweedler, M. Neuringer, M.J. Kuchan, J.W. Erdman, Jr., Exp. Biol. Med. (Maywood) 242, 2017, 305–315. DOI: 10.1177/1535370216675067

TOP

2016

Single-Cell Analysis at the Threshold, X. Chen, J.C. Love, N.E. Navin, L. Pachter, M.J.T. Stubbington, V. Svensson, J.V. Sweedler, S.A. Teichmann, Nat. Biotech. 34, 2016, 1111–1118. DOI:10.1038/nbt.3721

A D-Amino Acid-Containing Neuropeptide Discovery Funnel, I. Livnat, H-C Tai, E.T. Jansson, L. Bai, E.V. Romanova, T. Chen, K. Yu, S. Chen, Y. Zhang, Z. Wang, D. Liu, K.R. Weiss, J. Jing, J.V. Sweedler, Anal. Chem. 88, 2016, 11868–11876. DOI:10.1021/acs.analchem.6b03658

Label-Free Molecular Imaging of Bacterial Communities of the Opportunistic Pathogen Pseudomonas Aeruginosa, N. Baig, S. Polisetti, N. Morales-Soto, S.J.B. Dunham, J.V. Sweedler, J.D. Shrout, P.W. Bohn, Proc. SPIE 9930, Biosensing and Nanomedicine IX, 2016, 993004–993008. DOI:10.1117/12.2236695

A One-Step Matrix Application Method for MALDI Mass Spectrometry Imaging of Bacterial Colony Biofilms, B. Li, T.J. Comi, T. Si, S.J.B. Dunham, J.V. Sweedler, J. Mass Spectrom. 51, 2016,1030–1035. DOI:10.1002/jms.3827

Identification of Prohormones and Pituitary Neuropeptides in the African Cichlid, Astatotilapia burtoni, C. Hu, B.R. Southey, E.V. Romanova, K.P. Maruska, J.V. Sweedler, R.D. Fernald, BMC Genomics 17, 2016, 660. DOI:10.1186/s12864-016-2914-9

Single Cell Peptide Heterogeneity of Rat Islets of Langerhans, E.T. Jansson, T.J. Comi, S.S. Rubakhin, J.V Sweedler, ACS Chem. Biol. 11, 2016, 2588–2595. DOI:10.1021/acschembio.6b00602

On-tissue Derivatization Via Electrospray Deposition for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Endogenous Fatty Acids in Rat Brain Tissues, Q. Wu, T.J. Comi, B. Li, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 88, 2016, 5988–5995. DOI:10.1021/acs.analchem.6b01021

Characterization of Bacillus subtilis Colony Biofilms via Mass Spectrometry and Fluorescence Imaging, T. Si, B. Li, K. Zhang, Y. Xu, H. Zhao, J.V. Sweedler, J. Proteome Res. 15, 2016, 1955–1962. DOI:10.1021/acs.jproteome.6b00127

A Neuron-in-Capillary Platform for Facile Collection and Mass Spectrometric Characterization of a Secreted Neuropeptide, C.Y. Lee, Y. Fan, S.S. Rubakhin, S. Yoon, J.V. Sweedler, Sci. Rep. 6, 2016, 26940. DOI:10.1038/srep26940

Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea, T-H. Ong, E.V. Romanova, R.H. Roberts-Galbraith, N. Yang, T.A. Zimmerman, J.J. Collins III, J.E. Lee, N.L. Kelleher, P.A. Newmark, J.V. Sweedler, J. Biol. Chem. 291, 2016, 8109–8120. DOI:10.1074/jbc.M115.709196

Metal-assisted Polyatomic SIMS and Laser Desorption/Ionization for Enhanced Small Molecule Imaging of Bacterial Biofilms, S.J.B. Dunham, T.J. Comi, K. Ko, B. Li, N.F. Baig, N. Morales-Soto, J.D. Shrout, P.W. Bohn, and J.V. Sweedler, Biointerphases 11, 2016, 02A325. DOI:10.1116/1.4942884

Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-containing Neuropeptide, C.Y. Yang , K. Yu, Y. Wang, S.A. Chen, D.D. Liu, Z.Y. Wang, Y.N. Su, S.Z. Yang, T.T. Chen, I. Livnat, F.S. Vilim, E.C. Cropper, K.R. Weiss, J.V. Sweedler, J. Jing, PLOS ONE 11, 2016, e0147335. DOI:10.1371/journal.pone.0147335

TOP

2015

Effects of Exercise and Dietary Epigallocatechin Gallate and Beta-Alanine on Skeletal Muscle in Aged Mice, B.D. Pence, T.E. Gibbons, T.K. Bhattacharya, H. Mach, J.M. Ossyra, G. Petr, S.A. Martin, L. Wang, S.S. Rubakhin, J.V. Sweedler, R.H. McCusker, K.W. Kelley, J.S. Rhodes, R.W. Johnson, J.A. Woods, Appl. Physiol. Nutr. Metab. 41, 2015, 1–10. DOI:10.1139/apnm-2015-0372

Analytical Capabilities of Mass Spectrometry Imaging and its Potential Applications in Food Science, B. Li, S.J.B. Dunham, Y. Dong, S. Yoon, M. Zeng, J.V. Sweedler, Trends Food Sci. 47, 2015, 50–63. DOI:10.1016/j.tifs.2015.10.018

Lutein and Brain Function, J.W. Erdman Jr., J.W. Smith, M.J. Kuchan, E.S. Mohn, E.J. Johnson, S.S. Rubakhin, L. Wang,  J.V. Sweedler, M. Neuringer, Foods 4, 547–564. DOI:10.3390/foods4040547

Multimodal Chemical Imaging of Molecular Messengers in Emerging Pseudomonas Aeruginosa Bacterial Communities, N.F. Baig, S.J.B. Dunham, N. Morales-Soto, J.D. Shrout, J.V. Sweedler, P.W. Bohn, Analyst 140, 2015, 6544–6552. DOI:10.1039/c5an01149c

Peptidomics and Secretomics of the Mammalian Peripheral Sensory-Motor System, E.G. Tillmaand, N. Yang, C.A.C. Kindt, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 26, 2015, 2051–2061. DOI:10.​1007/​s13361-015-1256-1

Differential Peptidomics Assessment of Strain and Age Differences in Mice in Response to Acute Cocaine Administration, E.V. Romanova, S.S. Rubakhin, J.R. Ossyra, J.A. Zombeck, M.R. Nosek, J.V. Sweedler, J.S. Rhodes, J. Neurochem. 135, 2015, 1038-1048. DOI:10.1111/jnc.13265

Peptidomics for the Discovery and Characterization of Neuropeptides and Hormones, E.V. Romanova and J.V. Sweedler, Trends Pharmacol. Sci. 36, 2015, 579–586. DOI:10.1016/j.tips.2015.05.009

Classification of Large Cellular Populations and Discovery of Rare Cells Using Single Cell Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, T.H. Ong, D.J. Kissick, E.T. Jansson, T.J. Comi, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 87, 2015, 7039–7042. DOI:10.1021/acs.analchem.5b01557

Microbeam-Coupled Capillary Electrophoresis, G. Garty, M.U. Ehsan, M. Buonanno, Z. Yang, J.V. Sweedler, D.J. Brenner, Radiat. Prot. Dosimet. 166, 2015, 188–191. DOI:10.1093/rpd/ncv148

Rapid Mitogenic Regulation of the Mtorc1 Inhibitor, Deptor, by Phosphatidic Acid, M.S. Yoon, C.L. Rosenberger, C. Wu, N. Truong, J.V. Sweedler, J. Chen, Mol. Cell 58, 2015, 549–556. DOI:10.1016/j.molcel.2015.03.028

Nanopipet-Based Liquid-Liquid Interface Probes for the Electrochemical Detection of Acetylcholine, Tryptamine, and Serotonin Via Ionic Transfer, M.L. Colombo, J.V. Sweedler, M. Shen, Anal. Chem. 87, 2015, 5095–5100. DOI:10.1021/ac504151e

Mass Spectrometry Imaging and GC-MS Profiling of the Mammalian Peripheral Sensory-Motor Circuit, S.S. Rubakhin, A. Ulanov, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 26, 2015, 958–966. DOI:10.1007/s13361-015-1128-8

Mass Spectrometry-based Characterization of Endogenous Peptides and Metabolites in Small Volume Samples, T-H. Ong, E.G. Tillmaand, M. Makurath, S.S. Rubakhin, J.V. Sweedler, Biochim. Biophys. Acta 1854, 2015, 732–740. DOI:10.1016/j.bbapap.2015.01.008

Integration of Untargeted Metabolomics with Transcriptomics Reveals Active Metabolic Pathways, K. Cho, B.S. Evans, B.M. Wood, R. Kumar,  T.J. Erb, B.P. Warlick, J.A. Gerlt, J.V. Sweedler, Metabolomics 11, 2015, 503–517. DOI:10.​1007/​s11306-014-0713-3

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2014

Identification of Best Indicator of Peptide-Spectrum Match Using a Permutation Resampling Approach, M.N. Akhtar, B.R. Southey, P.E. Andrén, J.V. Sweedler, S.L. Rodriguez-Zas, J. Bioinform. Comput. Biol. 12, 2014, 1440001. DOI:10.1142/S0219720014400010

Accurate Assignment of Significance to Neuropeptide Identifications Using Monte Carlo K-Permuted Decoy Databases, M.N. Akhtar, B.R. Southey, P.E. Andrén, J.V. Sweedler, S.L. Rodriguez-Zas, PLOS ONE 9, 2014, e111112. DOI:10.1371/journal.pone.0111112

Correlated Imaging with C60-SIMS and Confocal Raman Microscopy: Visualization of Cell-scale Molecular Distributions in Bacterial Biofilms, E.J. Lanni, R.N. Masyuko, C.M. Driscoll, S.J.B. Dunham, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem. 86, 2014, 10885-10891. DOI:10.1021/ac5030914

Analysis of Endogenous Nucleotides by Single Cell Capillary Electrophoresis-Mass Spectrometry, J-X. Liu, J.T. Aerts, S.S. Rubakhin, X-X. Zhang, J.V. Sweedler, Analyst 139, 2014, 5835–5842. DOI:10.1039/C4AN01133C

Biomolecular Imaging with a C60-SIMS/MALDI Dual Ion Source Hybrid Mass Spectrometer: Instrumentation, Matrix Enhancement, and Single Cell Analysis, E.J. Lanni, S.J.B. Dunham, P. Nemes, S.S. Rubakhin, J.V. Sweedler, J. Amer. Soc. Mass Spectrom. 25, 2014, 1897–1907. DOI:10.1007/s13361-014-0978-9

MALDI-Guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms, E.J. Lanni, R.N. Masyuko, C.M. Driscoll, J.T. Aerts, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem. 86, 2014, 9139–9145. DOI:10.1021/ac5020222

Spatial Organization of Pseudomonas Aeruginosa Biofilms Probed by Combined Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Confocal Raman Microscopy, R.N. Masyuko, E.J. Lanni, C.M. Driscoll, J.D. Shrout, J.V. Sweedler, P.W. Bohn, Analyst 139, 2014, 5700–5708. DOI:10.1039/c4an00435c

The Ctenophore Genome and the Evolutionary Origins of Neural Systems, L.L. Moroz, K.M. Kocot, M.R. Citarella, S. Dosung, T.P. Norekian, I.S. Povolotskaya, A.P. Grigorenko, C. Dailey, E. Berezikov, K.M. Buckley, A. Ptitsyn, D. Reshetov, K. Mukherjee, T.P. Moroz, Y. Bobkova, F. Yu, V.V. Kapitonov, J. Jurka, Y.V. Bobkov, J.J. Swore, D.O. Girardo, A. Fodor, F. Gusev, R. Sanford, R. Bruders, E. Kittler, C.E. Mills, J.P. Rast, R. Derelle, V.V. Solovyev, F.A. Kondrashov, B.J. Swalla, J.V. Sweedler, E.I. Rogaev, K.M. Halanych, A.B. Kohn, Nature 510, 2014, 109–114. DOI:10.1038/nature13400

Fibrinogen-α Chain-derived Peptide is Upregulated in Hippocampus of Rats Exposed to Acute Morphine Injection and Spontaneous Alternation Testing, A.E. Maki, K.A. Morris, K. Catherman, X. Chen, N.G. Hatcher, P.E. Gold, J.V. Sweedler, Pharma. Res. Perspect. 2, 2014, e00037. DOI:10.1002/prp2.37

d-Alanine in the Islets of Langerhans of Rat Pancreas, N. Ota, S.S. Rubakhin, J.V. Sweedler, Biochem. Biophys Res. Commun. 447, 2014, 328–333. DOI:10.1016/j.bbrc.2014.03.153

Application of Capillary Electrophoresis for the Early Diagnosis of Cancer, Z. Yang and J.V. Sweedler, Anal. Bioanal. Chem. 406, 2014, 4013–4031. DOI:10.1007/s00216-014-7722-y

Patch Clamp Electrophysiology and Capillary Electrophoresis–Mass Spectrometry Metabolomics for Single Cell Characterization, J.T. Aerts, K.R. Louis, S.R. Crandall, G. Govindaiah, C.L. Cox, J.V. Sweedler, Anal. Chem. 86, 2014, 3203–3208. DOI:10.1021/ac500168d

Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine, R. Kumar, S. Zhao, M.W. Vetting, B.M. Wood, A. Sakai, K. Cho, J. Solbiati, S.C. Almo, J.V. Sweedler, M.P. Jacobson, J.A. Gerlt, J.E. Cronan, MBio 5, 2014, e00933-00913. DOI:10.1128/mBio.00933-13

Comparing Label-free Quantitative Peptidomics Approaches to Characterize Diurnal Variation of Peptides in the Rat Suprachiasmatic Nucleus, B.R. Southey, J.E. Lee, L. Zamdborg, N. Atkins, Jr., J.W. Mitchell, M. Li, M.U. Gillette, N.L. Kelleher, J.V. Sweedler, Anal. Chem., 86, 2014, 443–452. DOI:10.1021/ac4023378

Small-Volume Analysis of Cell-Cell Signaling Molecules in the Brain, E.V. Romanova, J.T. Aerts, C.A. Croushore, J.V. Sweedler, Neuropsychopharmacology 39, 2014, 50–64. DOI:10.1038/npp.2013.145

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