Cell to cell communication in the brain uses a diverse set of molecules, ranging from gaseous molecules such as nitric oxide (NO), classical transmitters such as glutamate, surprising molecules such as d-serine and a range of peptides.  The Sweedler group studies these to understand how networks of neurons and associated supporting cells such as glia can work together to yield emergent properties that give rise to behaviors and memory.  Specific questions address what molecules are present in specific cells and networks, how they change based on behavior or exposure to drugs, as well as their function. 

Several of the projects we are most involved with are:

Measuring Nitric Oxide and Nitric Oxide-Related
Compounds in Neurons

Neuropeptidomics

Examining the Distribution, Release and
Biosynthesis of D-Amino Acids

Understanding Serotonin Catabolism